Figure 5.
UV-induced loss of H2A.Z occupancy requires GG-NER complex-dependent nucleosome remodeling around GCBSs. (A) The UV-induced change to H2A.Z occupancy in wild-type cells around GCBS-associated TSSs is shown here using H2A.Z ChIP-seq data, prior to UV irradiation and 0 or 60 min after UV damage. The light gray trace represents the nucleosome positioning in the absence of DNA damage retrieved from the data shown in Figure 4. The inset highlights the UV-induced changes to H2A.Z occupancy at the +1 position. (B) As described in A, but now representing the H2A.Z occupancy at GCBS-bound promoter regions in GG-NER–defective RAD16-deleted cells.
