Accelerated rates of large-scale mutations in the presence of copper and nickel

Relative read depth at four CNV loci. Read depth (log₂ coverage) between genomes with a large-scale mutation (genomic deletions and duplications) and the average of all other MA lines is shown, in which a ratio above zero (blue) indicates the focal genome has more coverage than average, and a ratio below zero (red) indicates the focal genome has less coverage. (A) Duplication in the NiCu line C376 overlapping an uncharacterized single-copy gene (DAPPUDRAFT_325978). (B) Deletion in Con line C40 overlapping an uncharacterized single-copy gene (DAPPUDRAFT_114421) and several multiple-copy genes. (C) A duplication in C376 and (D) a deletion in C40 that lead to a partial gene CNV in the mre11 gene (DAPPUDRAFT_188962) and a neighboring uncharacterized gene (DAPPUDRAFT_227378).