Defining TP53 pioneering capabilities with competitive nucleosome binding assays

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Figure 5.
Figure 5.

Model of TP53 binding to targets within nucleosomes. TP53 scans DNA in a sequence-independent manner and targets p53BS located at the nucleosome edge. Once bound, TP53 can recruit cofactors and histone acetyltransferases (HATs).

This Article

  1. Published in Advance November 8, 2018, doi: 10.1101/gr.234104.117 Genome Res. 29: 107-115

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