Figure 4.
Nucleosome occupancy at TP53 nutlin-induced binding sites. (A) Average nucleosome occupancy at induced TP53 binding sites determined from MNase-seq. TP53 ChIP-seq results from Sammons et al. (2015) with MNase-seq data from Kelly et al. (2012; Sammons et al. 2015). The MNase-seq reads were extracted, standardized (1 billion reads), and extended with ArchTEx (Lai et al. 2012). (B) Nucleosome occupancy at each p53BS (±1000-bp) after nutlin-induced TP53 binding. Standardized and extended MNase-seq reads were clustered by symmetry (Lai and Buck 2010).
