Defining TP53 pioneering capabilities with competitive nucleosome binding assays

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Figure 3.
Figure 3.

TP53 has higher affinity to p53BS near nucleosome boundaries. (A–C) The sequence results for the nucleosome bands were used to determine the binding affinities, KD, with nonlinear regression. (A) The percentage of nucleosomes bound by TP53 as TP53 is titrated. The location of the high-affinity p53BS is indicated. (B) The percentage of nucleosomes bound by TP53 as TP53 is titrated. The location of the low-affinity p53BS is indicated. (C) KD values with standard errors were plotted for each nucleosome.

This Article

  1. Published in Advance November 8, 2018, doi: 10.1101/gr.234104.117 Genome Res. 29: 107-115

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