Variant antigen repertoires in Trypanosoma congolense populations and experimental infections can be profiled from deep sequence data using universal protein motifs

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 4.
Figure 4.

Phylotype variation across the sample cohort. The heatmap represents phylotype variation across the sample cohort expressed as the deviation from the mean. The dendrogram reflects the relationships among the VSG repertoires of each strain. Strains are color-coded by location of collection according to the key. Labels “i” to “ii” denote examples of phylotype variation signatures referred to in the text. Label “i” shows a pattern of underrepresented P1-3 among strains of multiple countries; “ii” shows a pattern of overrepresented P5-6 in Gambian isolates; “iii” shows a pattern of underrepresented P15 common to Forest-subtype isolates.

This Article

  1. Genome Res. 28: 1383-1394

Preprint Server