Typical X-WGBS results in IMR-90 and GM12878 cell lines. The green wiggle track represents the proportion of methylated DNA at each CG dinucleotide in a ∼100-kb region on Chromosome 2, with annotations of low-methylated regions (LMRs), histone post-translational modifications, and transposase-accessible chromatin also shown. We also show allele-specific methylation (ASM) at the rs11686156 single nucleotide polymorphism which is heterozygous in GM12878 and flanked by unmethylated DNA for the C allele (blue) and methylated DNA for the A allele (red). A differentially methylated region (DMR), where DNA methylation is higher in IMR-90 than GM12878 cells, is apparent at the site of the LMRs on the left of the region shown.
