Figure 1.
Discovery (A) and replication (B) of the deconvolution algorithm using lineage-invariant, developmentally sensitive CpG loci in newborn and adult peripheral blood leukocytes. Estimated mean percentage (standard deviation [SD]) FCO methylation fractions are 85.4% (6.0) for umbilical cord blood (UCB) and 0.6% (1.7) for peripheral adult blood in A; P = 2.11 × 10−191. In the replication (B), estimated FCO methylation fractions are 89.9% (3.8) for UCB and 2.0% (3.5) for peripheral adult blood; P = 8.35 × 10−81.
