Overlap between genetic variants associated with various complex traits and identified OCRs assayed using LD-score partitioned heritability. (A) Overlap between cell-type– and region-specific OCRs and genetic risk variants of various traits. The region-specific OCRs are based only on neuronal samples. (B) Overlap between all OCRs identified in 14 brain regions by two cell types and schizophrenia genetic risk variants. OCRs were in all cases padded with 1000 bp to also capture adjacent genetic variants. (Chronotype) whether one is a morning or an evening person; (·) nominally significant; (#) significant after FDR correction of multiple testing across all traits and OCRs sets.
