A common pattern of DNase I footprinting throughout the human mtDNA unveils clues for a chromatin-like organization

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Figure 6.
Figure 6.

Gain of mt-DGF site at the transcription-replication switch site, upon IL3-dependent activation of CD34+ cells. (A) Representation of the F-scores around the Light strand transcription start site: (y-axis) F-score; (x-axis) mtDNA position; (lowest F-score) most DNase I protected region; (thick line) average of F-scores across the analyzed samples; (dotted line) F-score calculated for single experiments; (red) control experiment; (gray) experiments of treated cells. (B) mtDNA copy number in control and treated cells.

This Article

  1. Genome Res. 28: 1158-1168

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