Switching roles for DNA and histone methylation depend on evolutionary ages of human endogenous retroviruses

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Figure 3.
Figure 3.

EHMT2, SETDB1, and SUV39H1 are required to maintain silencing of some LTRs in HCT116 cells. (A) The expression of up-regulated 791 intergenic LTRs after knockdown (KD) of represented genes. Red indicates the expression level of LTRs based on total RNA-seq in Nontarget (control), SETDB2, SUV39H2, EZH2, TRIM28, EHMT2, SETDB1, and SUV39H1 KD samples. (B) The fold expression changes in SETDB1 and SUV39H1 KD samples.

This Article

  1. Published in Advance July 3, 2018, doi: 10.1101/gr.234229.118 Genome Res. 28: 1147-1157

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