Figure 1.
Relative position of breaks of synteny differentially affects TAD integrity. Alternative consequences of hypothetical ancestral inversions (top) are demonstrated. TADs are represented with triangles and positions of breaks of synteny (BOS) are depicted with dotted lines. (A) BOS occurring at TAD boundaries in the ancestral genome, rearrange TADs as intact modules. (B) BOS within TAD bodies disrupt ancestral TADs and may give rise to new TADs in the gibbon genome. Moreover, a new TAD boundary (green diamond) can emerge within an ancestral TAD.
