Base-specific mutational intolerance near splice sites clarifies the role of nonessential splice nucleotides

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Figure 2.
Figure 2.

Singleton ratios adjusted by mutability at near-splice sites (left panel) compared to ExAC missense, nonsense (middle panel), and missense split by CADD (right panel) as references. “D + 10” and “D − 10” represent singleton ratios from an arbitrary intronic site and an arbitrary exonic site, respectively, and therefore serve as negative controls.

This Article

  1. Published in Advance June 1, 2018, doi: 10.1101/gr.231902.117 Genome Res. 28: 968-974

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