Sidi Zhang; Kaitlin E. Samocha; Manuel A. Rivas; Konrad J. Karczewski; Emma Daly; Ben Schmandt; Benjamin M. Neale; Daniel G. MacArthur; Mark J. Daly

Base-specific mutational intolerance near splice sites clarifies the role of nonessential splice nucleotides

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Figure 1.

Quantification of intolerance to mutations split by positions and reference alleles. (A) Nomenclature used throughout this study; (B) χ² statistics at the 5′ end; (C) χ² statistics at the 3′ end; (D) odds ratios at the 5′ end; (E) odds ratios at the 3′ end.