Long genes linked to autism spectrum disorders harbor broad enhancer-like chromatin domains

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Figure 6.
Figure 6.

Human orthologs of BELD genes and their expression in autistic individuals. (A) Heatmaps of normalized signals of H3K27ac in human orthologs of the mouse BELD (BELD) and non-BELD control genes (non-BELD). (PFC) Prefrontal cortex: (dlPFC) dorsolateral prefrontal cortex. (B) Boxplots of H3K27ac RPKMs in gene body regions of non-BELD control genes and BELD genes. P indicates P-value, one-tailed t-test. (C) Browser representation of H3K27ac ChIP-seq from human PFC at three BELD genes. (D) Boxplots of expression changes of human non-BELD control genes and BELD genes in the PFC of autistic individuals. P indicates P-value, one-tailed t-test.

This Article

  1. Published in Advance May 30, 2018, doi: 10.1101/gr.233775.117 Genome Res. 28: 933-942

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