Chromatin modifications in gene bodies of BELD genes. (A) Heatmaps of normalized signals (reads per 30 million uniquely mapped reads [RP30M]) of ChIP-seq and ATAC-seq across the gene bodies and surrounding regions (±100 kb) of the BELD genes and non-BELD control genes. (B) Browser representations of GRO-seq, ChIP-seq, ATAC-seq, mC, and hmC signals at nine long genes. The first seven genes are BELD genes linked to ASDs, while the last two genes are non-BELD genes. (C) Boxplot representations of H3K27ac RPKMs in the gene bodies of BELD genes and non-BELD control genes at four developmental time points. P indicates P-value, pairwise t-test adjusted by the Benjamini-Hochberg method.
