Figure 2.
Experimental validation of Chr7_inv10 inversion. (A) UCSC Genome Browser view of Chr7_inv10 (hg38_panTro5_30), exclusively predicted in the chimpanzee lineage. BES pair mapping of primate clones and their Illumina sequencing (reads in the colored frames) show that all primates analyzed carry the inverted orientation. Discordant clones spanning the inversion breakpoints appear to be discontinuous due to the presence of the inversion. (B) The same inversion has been further validated by FISH in human (GM12878), chimpanzee (PTR8), gorilla (GGO2), orangutan (PPY9), and macaque (MMU2) individuals using the FISH clones shown in panel A.
