FAM208A binds primarily to ERVs and L1 elements. (A) Reads from TI and FAM208A IP samples were mapped to rodent Repbase. Duplicates were averaged and RPKM ratios calculated between TIs and IPs. Repeats were selected giving ≥fourfold enrichment in the IPs. The ERV2 class includes ERVK elements from ETN and IAP families. (B) All L1 elements from A are displayed here with family name and age. (C) After mapping reads to mm10, 1045 peaks were identified (present in both duplicates and not in the TIs). (D) Peaks from C were sorted into those that clustered by their presence within 50 kb of a second FAM208A peak. (E) Intersection of FAM208A peaks with H3K9me3 peaks (either any overlap or 80% overlap considered). (F) FAM208A peaks from C overlap with young versus inactive L1s. (G) TRIM28-FAM208A genes were assessed for the percentage that contain either an inactive L1 (from the families L1_Rod, L1MB7, L1_Mur1, L1_Mur2, L1_Mur3, Lx8, Lx9, and Lx10) or an ERVK within 20 kb.
