Conserved microRNA targeting reveals preexisting gene dosage sensitivities that shaped amniote sex chromosome evolution

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Figure 4.
Figure 4.

Z-W pairs have higher miRNA conservation scores than other ancestral Z-linked genes. (A) PCT score distributions of all gene–miRNA interactions involving the human orthologs of chicken Z-W pairs (n = 832 interactions from 28 genes) and other ancestral Z genes (n = 16,692 interactions from 657 genes). (***) P < 0.001, two-sided Kolmogorov–Smirnov test. (B) Mean gene-level PCT scores. (***) P < 0.001, two-sided Wilcoxon rank-sum test.

This Article

  1. Published in Advance February 15, 2018, doi: 10.1101/gr.230433.117 Genome Res. 28: 474-483

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