Conserved microRNA targeting reveals preexisting gene dosage sensitivities that shaped amniote sex chromosome evolution

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 2.
Figure 2.

X-Y pairs and X-inactivated genes have higher miRNA conservation scores than X escape genes. PCT score distributions of all gene–miRNA interactions involving (A) human X-Y pairs (n = 371 interactions from 15 genes), X-inactivated genes (n = 6743 interactions from 329 genes), and X escape genes (n = 1037 interactions from 56 genes). (**) P < 0.01, two-sided Kolmogorov–Smirnov test. (B) Mean gene-level PCT scores. (*) P < 0.05, (**) P < 0.01, two-sided Wilcoxon rank-sum test.

This Article

  1. Published in Advance February 15, 2018, doi: 10.1101/gr.230433.117 Genome Res. 28: 474-483

Preprint Server



Current Issue

  1. March 2026, 36 (3)
  1. Current Issue
  1. Alert me to new issues of Genome Research