Figure 1.
Conserved miRNA targeting of autosomal genes stratified by copy number variation in 59,898 human exomes. Probabilities of conserved targeting (PCT) of all gene–miRNA interactions involving nonduplicated and duplicated genes, further stratified as (A) deleted (gray, n = 69,339 interactions from 4118 genes; blue, n = 80,290 interactions from 3976 genes) or (B) not deleted (orange, n = 51,514 interactions from 2916 genes; purple, n = 72,826 interactions from 3510 genes). (***) P < 0.001, two-sided Kolmogorov–Smirnov test. (C) Mean gene-level PCT scores. (**) P < 0.01, (***) P < 0.001, two-sided Wilcoxon rank-sum test.
