Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations

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Figure 4.
Figure 4.

CCAT2 is overexpressed in MDS patients. (A,B) CCAT2 expression in CD34+ bone marrow cells of MDS patients and healthy individuals. (A) Comparison between healthy individuals and MDS patients. (B) Comparison between MDS patients who progressed and those who did not progress to secondary AML. (C) CCAT2 expression in CD34+ bone marrow cells of MDS patients with Trisomy 8, other genetic abnormalities, and healthy individuals. (D) CCAT2 expression in peripheral blood of MDS patients and healthy individuals. (E) Correlation between CCAT2 expression in MDS patients and their risk category (classified according to IPSS risk classification). (F) Correlation between CCAT2 expression and percent blasts in bone marrow and peripheral blood of MDS patients. Data are represented as median values ±95% confidence interval. (*) P < 0.05.

This Article

  1. Genome Res. 28: 432-447

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