Performance comparison between FIND and edgeR on simulated data. (A) Tile plot comparing the performance between FIND and edgeR given different window sizes (W), percentages of significantly variable KNNs (P) and fold-change values. For each fixed configuration, we ran 10 simulations and calculated the box plots shown in each tile. (B) An example simulation showing the positioning of the reported DCI by edgeR and FIND (blue and green) relative to the real signal (blue and orange) in a case in which FIND and edgeR have similar performance. We observed that regions reported by edgeR tend to be located far from the real signal. (C) Distribution of the distances of edgeR and FIND's false-positive signals relative to true DI regions. We observed that edgeR DIs tended to be more scattered in the heatmap, whereas FIND's results tended to be near the real signal.
