ZFX acts as a transcriptional activator in multiple types of human tumors by binding downstream from transcription start sites at the majority of CpG island promoters

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Figure 4.
Figure 4.

Combinatorial knockdown of ZFX and ZNF711 in MCF-7 cells. (A) ZFX and ZNF711 expression levels upon knockdown of ZFX, ZNF711, or both TFs in MCF-7. Comparisons of data sets that show a significant difference are marked with an asterisk (FDR <0.05). (B) Volcano plots demonstrating differential gene expression after knockdown (kd) of ZFX, ZNF711, or both TFs. (C) Comparison of down-regulated genes having ZFX bound at their promoters after knockdown of ZFX, ZNF711, or both TFs.

This Article

  1. Published in Advance February 2, 2018, doi: 10.1101/gr.228809.117 Genome Res. 28: 310-320

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