ZFX acts as a transcriptional activator in multiple types of human tumors by binding downstream from transcription start sites at the majority of CpG island promoters

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Figure 3.
Figure 3.

The role of ZFX in transcription regulation. Expression levels of genes with active promoters bound by ZFX and genes with active promoters not bound by ZFX are shown for C4-2B (A) and MCF-7 (D); active promoters are defined by detectable expression of a transcript from that promoter in that particular cell line. Volcano plots demonstrate differential gene expression after knockdown of ZFX in C4-2B (B) and MCF-7 (E). Comparisons of the percentage of down-regulated versus up-regulated genes that have ZFX bound at their promoters are shown for C4-2B (C) and MCF-7 (F) cells.

This Article

  1. Published in Advance February 2, 2018, doi: 10.1101/gr.228809.117 Genome Res. 28: 310-320

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