Figure 5.
Comparison of statistically significant uORFs in three Saccharomyces yeast species. Venn diagrams show the numbers of sequence-conserved (Methods) uORFs identified in each species and the number shared by multiple species, separated by start codon type. The number of shared uORFs generally follows phylogenetic relationships. uORFs initiating with TTG are shared by two or more species at rates comparable to AUG-uORFs, whereas other NCC uORFs are less commonly shared. Note that uORF start codon types were defined by the start codon used in S. cerevisiae or S. paradoxus. See Supplemental Figures S8 and S11 for a full breakdown of uORF orthologs.
