Figure 3.
Activated LTRs are binding sites for many transcription factors in GM12878 cells and can promote transcription. (A) Bar graphs of the percentage of activated LTRs bound by each transcription factor. (B) Correlation plots (Pearson's) of transcription factor co-occupancy at EBV-activated LTRs. Hierarchical clustering was performed to identify transcription factors that co-occur. (C) Percentage of activated LTRs with CAGE sequences in GM12878 cells, indicating promoter activity. (D) RT-qPCR of RUNX3, SORD2P, and NCF2 transcripts after siRNA knockdown of RUNX3 transcripts. (*) P < 0.05.
