LTRs activated by Epstein-Barr virus–induced transformation of B cells alter the transcriptome

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Figure 2.
Figure 2.

Activated LTRs are hypomethylated in LCLs. (A, left) Heatmap of H3K4me3 in three B cell donors and three matched LCLs at activated LTRs; (right) heatmap of DNA methylation changes in matched B cells and LCLs at activated LTRs. (B) Genome browser tracks of DNA methylation and H3K4me3 profiles in B cells and LCLs at a SORD2P locus driven by an LTR8. (C) Boxplot of DNA methylation changes (left) and H3K4me3 change (right) between B cells and LCLs stratified into quartiles based on DNA methylation change.

This Article

  1. Published in Advance October 31, 2018, doi: 10.1101/gr.233585.117 Genome Res. 28: 1791-1798

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