LTRs activated by Epstein-Barr virus–induced transformation of B cells alter the transcriptome

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Figure 1.
Figure 1.

EBV-induced transformation of B cells activates LTRs. (A) Genome browser tracks of H3K4me3 profiles at LINC02363, a long noncoding gene, with the MLT1G LTR at the transcriptional start site (TSS). (B) Volcano plots of normalized H3K4me3 read counts in LCLs relative to B cells at TSSs of genes (top) and at LTRs (bottom). (C) Percentage of differentially enriched H3K4me3 LTRs and genes classified as “activated,” “up-regulated,” “down-regulated,” and “repressed.” (D) Enumeration of the LTR families that are activated in LCLs (Group I).

This Article

  1. Published in Advance October 31, 2018, doi: 10.1101/gr.233585.117 Genome Res. 28: 1791-1798

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