HRSs are associated with the active chromosomal compartment. (A) Comparison between A and B compartments, StyI fragment, HRS, and gene densities along mouse Chromosome 1. (B) For each chromosome, the overlap score between ESC HRSs and the active A compartment has been calculated (red dot) and compared to the overlap scores obtained for 1000 randomizations (box plots). The overlap score represents the fraction of the genomic feature of interest (here A compartment) that is covered by HRS. The P-value (valid independently for each chromosome) assesses the difference between the overlap scores obtained for HRSs versus 1000 randomizations. (C) Analyses of overlap scores for the inactive B compartment were performed as described above.
