Phenotypically distinct female castes in honey bees are defined by alternative chromatin states during larval development

Profiles of two genes that show a significant difference in both ChIP-seq enrichment and transcript expression between castes. (A) Pyruvate kinase (PYK; LOC552007). Regions are shown which reach genome-wide significance (P ≤ 0.01) and have a greater than threefold difference in enrichment over input between 96hW (blue) and 96hQ (red). The expression profile is shown in the right panel. (B) Ten-eleven translocation (TET; LOC412878). Regions are shown which reach genome-wide significance (P ≤ 0.01) and have a greater than threefold difference in enrichment over input between 96hW (blue) and 96hQ (red) for both TET transcripts, XM_016915488 (upper transcript) and XM_006561197 (lower transcript). The expression profile is also shown for transcripts XM_016915488 (left) and XM_006561197 (right).