Study of mitotic chromatin supports a model of bookmarking by histone modifications and reveals nucleosome deposition patterns

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Figure 4.
Figure 4.

The nucleosome that enters the NDR during mitosis is distinguishable from the surrounding nucleosomes. Top: Heat maps showing the normalized and standardized read depth at 6-kb regions centered at either TSSs, enhancers, or insulators, for H3K4 methylation (n = 6488, 7062, 4367, respectively) (A), and H3K9 or H3K27 acetylation (n = 6808, 5565, 3033, respectively) (B). Bottom: Metagene plots showing the average read depth for all regions in each category are under the relevant heat map. Similar plots for additional modifications as well as a biological repeat are shown in Supplemental Figures S5–S7.

This Article

  1. Genome Res. 28: 1455-1466

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