INSIGHT estimates for different sets of ESE motifs. (A) INT3; (B) ESR; (C) RESCUE; (D) PESE; (E) Ke; and (F) all sets combined (except for Ke). (ρ) Fraction of sites under selection; (α) fraction of divergences driven to fixation by positive selection; (η) scaling factor on the divergence rate at selected sites; (τ) fraction of polymorphisms under weak negative selection; (γ) scaling factor on the site frequency spectrum at selected sites. Human CpG-filtering is expected to be more reliable for ρ, τ, and γ; ancestral CpG-filtering is expected to perform better for α and η. An asterisk (*) indicates an empirical one-tailed P-value of <0.05. There are no P-values for α and τ. NB: For visualization purposes, the η and γ values for Ke (ancestral CpG-filtering) have been capped at one. The true values are η ≈ 10.625 and γ ≈ 28.543.
