Figure 1.
Distribution of INSIGHT statistics from 100 negative control runs using different methods of CpG-filtering. (N) No filtering; (H) human filtering; (A) ancestral filtering. Human filtering has the lowest false-positive rate for ρ (the fraction of sites under selection; A) and for τ (the fraction of polymorphisms under weak negative selection; C). Ancestral filtering performs best for α (the fraction of divergences driven to fixation by positive selection; B).
