Tissue-specific DMRs. (A) DMR counts for TSSs and CpG islands and Pearson correlation analysis of TSSs upon in silico dilution starting with 150 million reads. (B) DNA was collected of available organs (green) from 10 different female patients. (C) Correlation analysis of TSS read counts between blood samples of different patients. (D) Correlation analysis of TSS read counts between different organs of the same patients. (E) MeD-seq tracks of ribosomal RNA cluster in DNA of blood and thyroid from patients 8, 3, and 4. (F) Unsupervised hierarchical clustering of tissues based on differentially methylated CpG islands. Statistical significance was called by χ2 testing and Bonferroni correction, the Z-scores of the read count are shown in the heatmap. (G) MeD-seq tracks of the HOXB and HOXD loci displaying differential methylation in TSS and CpG islands in different tissues.
