Modeling complex disease using iPSC-derived cells. (A) Heat map of enrichment P-values of GWAS signals near genes with cell-type–specific expression (Supplemental Materials). (B) Enrichments of SNPs associated with four different diseases in different partitions of the genome (computed using LDscore regression; point estimates ±95% confidence intervals). In both analyses, the autoimmune traits (multiple sclerosis [MS] or Crohn's disease [CD] and rheumatoid arthritis [RA]) show enrichment near genes and chromatin that are more active in LCLs, and the heart-related traits (coronary artery disease [CAD] and myocardial infarction [MI]) are enriched in iPSC-CM active regions.
