Lineage-specific expansion and expression changes in amniotes. Duplication events are marked with blue squares. Ensembl gene IDs and species are shown at the tips of the trees. Circles represent expression patterns, with circle color corresponding to the tissue of the highest expression of the respective gene. (A) The gene family (Fam612) containing guanylate binding peptides has expanded independently in mouse, opossum, platypus, and chicken. Note multiple lineage-specific changes in tissue preference. (B) Independent lineage-specific duplications in primates and marsupials. Expansions along the primate lineage produced paralogs with high brain-specific expression, whereas the majority of opossum genes show low liver-specific expression.
