Human mismatch repair system balances mutation rates between strands by removing more mismatches from the lagging strand

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Figure 6.
Figure 6.

The schematic representation of MMR effectiveness during the leading and the lagging strand replication. While mismatches (red asterisks) are introduced more frequently during replication of the lagging strand by Pol delta, MMR corrects more mismatches on the lagging strand.

This Article

  1. Published in Advance May 16, 2017, doi: 10.1101/gr.219915.116 Genome Res. 27: 1336-1343

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