Figure 5.
Strand asymmetry of mutations in MSI cancers and in bMMRD cancers with mutated Pol epsilon and Pol delta cancers. (A) The asymmetry for complementary mutations in the 20% of the genome where replication asymmetry could be determined with the highest confidence (corresponding to bins 1 and 10 in Figs. 2B, 4). Error bars, 95% confidence intervals. (B) Model-estimated ratio of MMR effectiveness on the lagging and the leading strands.
