Human mismatch repair system balances mutation rates between strands by removing more mismatches from the lagging strand

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Figure 4.
Figure 4.

Strand asymmetry of mutations. Panels show ratios of the mutation rates for complementary mutations in 10 MSI (three COAD and seven UCEC) and 22 MSS (eight COAD and 14 UCEC) cancers and in rare human polymorphisms. Whole-genome data used. Axes and notations are as in Figure 2B.

This Article

  1. Published in Advance May 16, 2017, doi: 10.1101/gr.219915.116 Genome Res. 27: 1336-1343

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