Single-cell sequencing deciphers a convergent evolution of copy number alterations from primary to circulating tumor cells

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Figure 2.
Figure 2.

Evolution of focal CNAs in primary tumor cells and CTCs. (A) Visualization of aligned reads around a focal region of Chromosome 10 (Chr 10: 86,880,000–98,090,000) containing the PTEN gene. The bin size was 50 kb. The maximal ordinate coordinate values were set to reads corresponding to a copy number of 2. (B) Visualization of aligned reads around multiple focal regions of Chromosome 8 (Chr 8: 56,000,000–66,160,000; Chr 8: 123,850,000–133,210,000) containing the MYC gene. The bin size was 50 kb. The maximal ordinate coordinate values were set to reads corresponding to a copy number of 40.

This Article

  1. Published in Advance May 9, 2017, doi: 10.1101/gr.216788.116 Genome Res. 27: 1312-1322

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