Cover image
A depiction of a late-dissemination clonal lineage constructed from single-cell mutation data in a colon cancer patient. The lineage shows that single cells (circles) from a primary tumor evolved for an extended period of time before diverging to form a metastatic lineage in the liver (red). (Illustration by Aislyn Schalck, Alex Davis, and Nicholas Navin. [For details, see Leung et al., pp. 1287–1299.])
