The Leapfrog pipeline recovers hundreds of hidden orthologs in Platyhelminthes. (A) Distribution of hidden orthologs according to their identification in one or more of the analyzed transcriptomes. Most of the hidden orthologs are unique to each lineage. (B) Distribution of species-specific hidden orthologs in each studied species. (C) Amino acid alignment of a fragment of the centrosomal protein SDCCAG8 of H. sapiens, P. vittatus, and S. mediterranea, and pairwise comparison of conserved residues. Positions that differ between the human and the hidden ortholog products are conserved between P. vittatus and one or the other sequences. Black dots indicate residues conserved among the three species.
