Chromatin module inference on cellular trajectories identifies key transition points and poised epigenetic states in diverse developmental processes

Rule-based analysis of hematopoiesis CMINT modules identifies regions associated with chromatin state transitions at different lineage points. (A, left) Regions that belong to modules enriched for marks (numbered greater than 10) in MEP and depleted for marks (less than 4) in GMP and their module assignments in other cell types. (Right) Histone modification level in the regions that obey the MEP > 10 and GMP < 4 module membership rule. (B) Similar to A, but for regions that obey the GMP > 10 and MEP < 4 rule. (C) As in A, but for regions that obey the CMP > 10 and CLP < 4 rule. (D) As in A, but for regions that obey the opposite rule, CLP > 10 and CMP < 4.