Genome-wide TOP2A DNA cleavage is biased toward translocated and highly transcribed loci

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Figure 2.
Figure 2.

Regional TOP2A CCR sequence conservation. Lower SNP density within 100 nt at CCR centers compared with the surrounding 10 kb in 100-nt sliding windows. P < 2.2 × 10−16; Kruskal–Wallis test. Amplified samples; same treatments merged where applicable (Supplemental Table S1).

This Article

  1. Published in Advance April 6, 2017, doi: 10.1101/gr.211615.116 Genome Res. 27: 1238-1249

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