Pol III gene occupancy increase in CF, Arntl KO, and Maf1 KO mice. (A) ChIP-seq was performed with an antibody directed against POLR3D (RPC4), a Pol III subunit, with pools of three liver samples from 12- to 14-wk-old mice collected every 4 h during two consecutive days. Five hundred seventy-three loci significantly occupied by Pol III in at least one sample in one of the conditions were analyzed. (B) Box plot showing, for each of the 573 loci, the mean of all scores [log2(IP/Input)] in all time points (12 samples per condition) for control, CF, Arntl KO, and Maf1 KO liver samples. The mean and median of the 573 loci are represented with a black squared dot and a black line, respectively. (C) Box plot showing the mean score of two biological replicates at each time point for the 573 loci. (D) As in C, but for the Arntl KO mice. (E) As in C, but for the CF mice. (F) As in C, but for the Maf1 KO mice.
