Network of TFs with TF–TF interactions in the TRN highlighting tissue-specific and time-specific regulators. TFs whose targets were enriched for DEGs in FCX are orange, TFs whose targets were enriched for DEGs in HYP are dark gray, and TFs whose targets were enriched for DEGs in AMY are blue. The times after social challenge where enrichment was found are depicted as shapes: Square nodes are enriched at 30 min, circular nodes are enriched at 120 min, and diamond-shaped nodes are enriched at both 30 min and 120 min after challenge. Multicolored TF modules such as Pparg and Lhx2 were enriched for DEG in multiple regions or time points. TFs that were not enriched for any tissue-specific or time-specific DEG—shown as small nodes—may represent homeostatic processes active across all conditions.
