Cytosine modifications modulate the chromatin architecture of transcriptional enhancers

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Figure 2.
Figure 2.

De novo hydroxymethylated enhancers bind pioneer factors driving NPC commitment. (A) Average kinetic profiles of 5hmC, 5mC, H3K4me1, H3K27ac, and chromatin opening (FAIRE) at 20,492 regions gaining 5hmC (up-DhMRs) at 48 h of P19 ECC differentiation. (B) Average profiles of FOXA1, PBX1, and MEIS1 binding at up-DhMRs at 48 h of differentiation. (C) Heat map representations of 5hmC signal at MEIS1, PBX1, and FOXA1 enriched regions in 48 h RA-treated P19 cells.

This Article

  1. Published in Advance April 10, 2017, doi: 10.1101/gr.211466.116 Genome Res. 27: 947-958

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