Microbial strain-level population structure and genetic diversity from metagenomes

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Figure 3.
Figure 3.

Most strains are retained over time within the human gut, but few strains are carried by multiple subjects. The distribution of the all-versus-all normalized genetic distance between strains is reported for increasingly large metagenome collections (only MetaHIT, only the HMP, or all 1590 samples). For MetaHIT and the HMP, we also computed the intra-subject distances (temporal separation between samplings averaging 163 SD 125 d and 219 SD 69 d, respectively) normalized based on the median of the all-versus-all comparisons.

This Article

  1. Genome Res. 27: 626-638

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