Figure 2.
PRDM9 class 1, but not class 2, sites show signatures of GC-biased gene conversion. Points represent the equilibrium GC-content (GC*) estimated from the lineage-specific substitutions aggregated in 10-bp bins from the center of all peaks. GC* in M. m. domesticus and M. m. castaneus lineages are displayed in blue and red, respectively. Lines were obtained by fitting a cubic smoothing spline. (A) GC* centered on PRDM9 class 1 sites in B6 and RJ2 mice. (B) GC* centered on PRDM9 class 2 sites in B6 and RJ2 mice; the equilibrium GC-content (GC*) in M. m. domesticus and M. m. castaneus lineages are not significantly different (Student P-value = 0.65 and 0.99 for B6 and RJ2, respectively).
